With enough research, stem cells can be a big help to the human kind.
Stem cell research has incredible potential....
A self-replicating cell source, such as pluripotent stem cells, with the potential to differentiate into cardiomyocytes would represent an alternative in vitro system for cardiotoxicity. Earlier studies on murine ESC-derived cardiomyocytes have already demonstrated the potential of ESCs for safety pharmacology and toxicology (reviewed in Boheler et al. ; Wobus and Boheler ). Murine ESCs differentiating into the cardiac lineage yield several specialized cell types of the heart, such as atrial-, ventricular-, sinus nodal- and Purkinje-like cells. Cardiac-specific genes as well as proteins, receptors and ion channels are expressed in a developmentally controlled manner, which closely recapitulates the developmental pattern of early cardiogenesis in vivo (for reviews see Boheler et al. ; Filipczyk et al. ). Genetic manipulation, addition of extrinsic factors and extracellular matrix proteins, engineering the microenvironment as well as improvements in cultivation protocols have been shown to trigger the cardiac differentiation process and to increase the efficiency of cardiac differentiation (for reviews see Filipczyk et al. ; Chen et al. ; Perino et al. ; Puceat ; Reinecke et al. ; Horton et al. ). However, only human cell-based in vitro systems would overcome the problem of inter-species differences that limit the use of mESCs for cardiotoxicity testing. So far, much progress has been made in the differentiation of hESCs towards cardiomyocytes, and this knowledge is now being applied to hiPSCs. In the following sections, recent strategies for the generation of cardiomyocytes from human pluripotent stem cells, their characterization and methods for their enrichment will be summarized, and the potential of these cardiomyocytes in safety pharmacology and toxicology will be discussed.
Stem cell research is currently legal in most countries.
This act is considered to be murder by a great piece of the United States population, which has caused a crippling blow to stem cell research (as far as money and factual knowledge goes).